School of Neuroscience for Thai Youth

ÇÔ·ÂÒÈÒʵÃì¢Í§Ãкº»ÃÐÊÒ·ÊÓËÃѺà´ç¡áÅÐàÂÒǪ¹: ÊÁͧ ¨Ôµ ¾ÄµÔ¡ÃÃÁ Êѧ¤Á ªÒµÔ¾Ñ¹¸ØìÁ¹ØÉÂì

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1.¤ÇÒÁ¼Ô´»¡µÔ·Ò§»ÃÐÊÒ·ÇÔ·ÂÒ (Neurological Disorders)

2. ¤ÇÒÁ¼Ô´»¡µÔ·Ò§¨ÔµÍÒÃÁ³ì (Psychological Disorders)

  • âä¨ÔµàÀ· (Schizophrenia)
  • âä«ÖÁàÈÃéÒ (Depression)
  • âä¤ÃÖ¡¤Ã×é¹ (Mania)
  • âäÇÔµ¡¡Ñ§ÇÅ Anxiety Disorders)
  • áÅÐÍ×è¹æ

·ÕèÁÒ :  Pharmacology on the net  http://www.pharm.chula.ac.th/Surachai/Academic/Nurse/Nurse-01.htm

Alzheimer's Predictor: ScienCentral News Video

Central Nervous System Diseases

âäÁÑŵÔà¾ÔÅÊà¤ÅÍâëÔÊ Multiple sclerosis

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·ÕèÁÒ http://library.med.utah.edu/kw/ms/mml/ms_worldmap.html

 

                ª×èÍâäàÍçÁàÍʹÕéÁÒ¨Ò¡ÍÒ¡Òâͧâä ÁÒ¨Ò¡ÃÒ¡ÈѾ·ìÀÒÉÒ¡ÃÕ¡ “skleros” á»ÅÇèÒá¢ç§ ËÁÒ¶֧àËç¹ÃÍÂâäà»ç¹á¼è¹ËÃ×Íá¼Åà»ç¹ Êèǹ¤ÓÇèÒ “multiple” ËÁÒ¤ÇÒÁÇèÒá¼Åà»ç¹àËÅèÒ¹Õéà¡Ô´ä´éËÅÒµÓá˹è§ã¹Ãкº»ÃÐÊÒ·Êèǹ¡ÅÒ§ âäàÍçÁàÍʹÕéà¡Ô´¨Ò¡¡Ò÷ÓÅÒÂàÂ×èÍäÁÍÕÅÔ¹ (myelin sheath) «Ö觾ѹÍÂÙèÃͺæ àÊé¹ãÂáÍ¡«Í¹¢Í§à«ÅÅì»ÃÐÊÒ··ÕèÍÂÙèã¹Ãкº»ÃÐÊÒ·Êèǹ¡ÅÒ§ (Ãкº»ÃÐÊÒ·Êèǹ¡ÅÒ§ ËÁÒ¶֧ ÊÁͧáÅÐä¢ÊѹËÅѧ à«ÅÅì·ÕèÊÃéÒ§àÂ×èÍäÁÍÕÅÔ¹ã¹Ãкº»ÃÐÊÒ·Êèǹ¡ÅÒ§ ¤×Í à«ÅÅì·Õèª×èÍÇèÒâÍÅÔâ¡à´¹â´Ã䫵ì (oligodendrocyte)) àÁ×èÍàÂ×èÍäÁÍÕÅÔ¹¶Ù¡·ÓÅÒÂÊÅÒµÑÇ (Demyelination) ¨Ð·ÓãËé¡ÒùÓÊè§¢éÍÁÙÅËÃ×ÍÊÑ­­Ò³»ÃÐÊÒ·¢Í§à«ÅÅì»ÃÐÊÒ·à¡Ô´¤ÇÒÁ¼Ô´»¡µÔ àªè¹ à¡Ô´¤ÇÒÁÅèÒªéÒ㹡ÒùÓÊè§ÊÑ­­Ò³ ËÃ×Í ÍÒ¨à¡Ô´¡ÒûԴ¡Ñé¹ÊÑ­­Ò­Ò³»ÃÐÊÒ·¡çà»ç¹ä´é ¡ÒÃÊÙ­àÊÕÂàÂ×èÍäÁÍÕÅÔ¹¹Õé¨Ö§¶×Íà»ç¹ÃÒ¡à˧éҢͧ»Ñ­ËÒ·Õè·ÓãËéà¡Ô´ÍÒ¡ÒüԴ»¡µÔ¢Í§¡ÒùÓÊÑ­­Ò³»ÃÐÊÒ·ä»ÂѧÍÇÑÂÇеèÒ§æ ¢Í§ÃèÒ§¡ÒÂ


                                  

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·ÕèÁÒ http://www.mssociety.org.uk/

                               

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ÃÙ»¹ÕéáÊ´§ÀÒÇзÕèà¡Ô´¡Ò÷ÓÅÒÂàÂ×èÍäÁÍÕÅÔ¹à»ç¹¼ÅãËé¡ÒÃÊ×èÍÊÒÃÃÐËÇèÒ§à«ÅÅì»ÃÐÊÒ·áÅСѺÍÇÑÂÇТͧÃèÒ§¡ÒÂà¡Ô´¤ÇÒÁÅèÒªéÒáÅÐá»Ã»Ãǹ

·ÕèÁÒ http://www.mssociety.org.uk/

 

                   ÊÒà˵طÕè·ÓãËéà¡Ô´âä¹ÕéÂѧäÁè·ÃÒºá¹èªÑ´ áµèàª×èÍÇèÒà¡Ô´¨Ò¡»Ñ¨¨ÑÂËÅÑ¡ÊͧÊèǹ ¤×Í ¾Ñ¹¸Ø¡ÃÃÁ áÅÐÊÔè§áÇ´ÅéÍÁ ¹Ñ¡ÇԨѺҧÊèǹàª×èÍÇèÒÍÒ¨à¡Ô´¨Ò¡¡ÒõԴàª×éÍäÇÃÑÊËÃ×ÍẤ·ÕàÃÕ ºÒ§¡ÅØèÁàª×èÍÇèÒäÇÃÑÊ·Õèà¡Ô´¡ÒõԴàª×é͵͹ÇÑÂà´ç¡ÍҨ仡ÃеØé¹ãËéÃкºÀÙÁÔ¤ØéÁ¡Ñ¹¢Í§ÃèÒ¡Ò¼Դ»¡µÔ¨¹Ãкº´Ñ§¡ÅèÒÇÁÒ·ÓÅÒÂàÂ×èÍäÁÍÕÅÔ¹¢Í§ÃèÒ§¡ÒÂàͧ ·ÕèÊӤѭ¤×Í ËÒ¡àÃÒ;¾ä»ÍÂÙèã¹»ÃÐà·È·ÕèËèÒ§ä¡Å¨Ò¡àÊé¹ÈÙ¹ÂìÊٵà àªè¹ ÊËÃѰÍàÁÃÔ¡Ò ÊËÃÒªÍҳҨѡà ¹ÔÇ«ÕᏴì ÍÍÊàµÃàÅÕ ËÅѧ¨Ò¡ÍÒÂØ»Õ 15 áÅéÇ âÍ¡ÒÊ·ÕèàÃÒ¨Ðà»ç¹âä¹ÕéËÃ×ÍäÁè¹Ñé¹¢Öé¹ÍÂÙè¡Ñº»Ñ¨¨Ñ·Õèä´éÃѺ㹻ÃÐà·È·ÕèàÃÒÍÒÈÑÂÍÂÙè¡è͹˹éÒ¹Ñé¹ÁÒ¡¡ÇèһѨ¨Ñ·ÕèàÃÒ¨Ðä´éÃѺ¨Ò¡¡ÅØèÁ»ÃÐà·È·ÕèàÃÒÂéÒÂä»

                ÍÒ¡ÒÃâ´Â·ÑèÇ仢ͧ¼Ùé»èÇÂâäàÍçÁàÍÊÁÕËÅÒÂÅѡɳРàªè¹ ÁͧàËç¹äÁèªÑ´ µÒ¾ÃèÒÁÑÇ àÊé¹»ÃÐÊÒ·µÒÍÑ¡àʺ ᢹ¢ÒàÁ×èÍÂÅéÒäÁèÁÕáç ÃÙéÊÖ¡ÇèÒÃèÒ§¡ÒÂà˹×èÍÂÅéÒ ÃèÒ§¡ÒÂäÁèÊÒÁÒöÍÂÙèã¹µÓá˹觷ÕèÊÁ´ØÅ ¾Ù´ªéÒ¼Ô´»¡µÔ ¾ÄµÔ¡ÃÃÁËÃ×ÍÍÒÃÁ³ìà»ÅÕè¹á»Å§ ÁջѭËÒà¡ÕèÂǡѺÃкº»ÑÊÊÒÇÐ ÊÁÃöÀÒ¾·Ò§à¾ÈŴŧ ÃÇÁ·Ñé§ÊÙ­àÊÕ¤ÇÒÁ¨ÓÃÐÂÐÊÑé¹ à»ç¹µé¹  

ÍÂèÒ§äáçµÒÁâäàÍçÁàÍʹÕéäÁèãªèâäµÔ´µèÍ ¼Ùé»èÇÂáµèÅФ¹ÁÕÀÒÇТͧâäᵡµèÒ§¡Ñ¹ ºÒ§ÃÒÂÍÒ¨áÊ´§ÍÒ¡ÒÃà»ç¹¤ÃÑ駤ÃÒÇ ã¹¢³Ð·ÕèºÒ§ÃÒÂÁÕÍÒ¡ÒÃ˹ѡ¢Öé¹µÒÁàÇÅÒ áµè·ÕèÊӤѭ¤×ͼÙé»èÇ·ء¤¹äÁèÊÒÁÒö·Õè¨Ð¤Ò´à´Òä´éÇèÒ¨Ðà¡Ô´ÍÒ¡ÒÃàÁ×èÍã´ Åѡɳдѧ¡ÅèÒǹÕé·ÓãËé¡ÒÃãªéªÕÇÔµ»ÃШÓÇѹ áÅСÒûÃСͺÍÒªÕ¾ä´éÃѺ¼Å¡ÃзºÍÂèÒ§ÂÔè§ ¼Ùé»èǺҧÃÒ·ÕèÁÕÍÒÂØ¹éÍÂÍÒ¨¶Ö§¢Ñ鹷ؾ¾ÅÀÒ¾

 

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·ÕèÁÒ http://www.netterimages.com/image/1167.htm

1.       ¡Ò÷´Êͺ·Ò§»ÃÐÊÒ·ÇÔ·ÂÒ (Neurological examination) àªè¹ Êͺ¶ÒÁ»ÃÐÇѵÔÍÒ¡ÒÃã¹Í´Õµ µÃǨ¡Ò÷ӧҹ¢Í§µÒ ¡Ò֍µÑÇ ¡ÒÃÃѺÊÑÁ¼ÑÊ áÅл¯Ô¡ÔÃÔÂÒÃÕà¿Åç¡«ì (reflex action) à»ç¹µé¹

2.       ¡ÒÃãªéà¤Ã×èͧµÃǨÊ᡹·ÕèàÃÕ¡ÇèÒ à¤Ã×èͧàÍçÁÍÒÃìäÍ (Magnetic Resonance Imaging; MRI) «Öè§ÊÒÁÒöàËç¹ÀÒ¾¢Í§ÊÁͧËÃ×Íä¢ÊѹËÅѧµÓá˹觷ÕèàÂ×èÍäÁÍÕÅÔ¹¶Ù¡·ÓÅÒÂáÅÐÁÕ¡ÒÃÊÅÒµÑÇàËç¹à»ç¹ÃÍÂá¼Åà»ç¹ã¹ÀÒ¾

                                            

3.       ¡Ò÷´Êͺ·Ò§ÊÃÕÃÇÔ·ÂÒä¿¿éҢͧÊÁͧ·ÕèàÃÕ¡ÇèÒ “Evoked potentials” ¤×Í ¡ÒõÃǨÊͺ¤ÇÒÁàÃçǨҡÊÔè§¡ÃеØé¹ à»ç¹µé¹ÇèÒ àÊÕ§ËÃ×ÍÀÒ¾·ÕèÊè§ä»ÂѧÊÁͧ ËÃ×ͤÇÒÁàÃçǢͧ¡ÒÃÊÑè§¡ÒèҡÊÁͧä»ÂѧÍÇÑÂÇÐÍ×è¹æÇèÒÁÕ¤ÇÒÁÅèÒªéÒ¡ÇèÒ»¡µÔËÃ×ÍäÁèÍÂèÒ§äÃ

4.       ¡ÒÃà¨ÒÐä¢ÊѹËÅѧ·ÕèàÃÕ¡ÇèÒ ”Lumbar puncture” à¾×èÍ´Ù´àÍÒ¹éÓàÅÕé§ÊÁͧáÅÐä¢ÊѹËÅѧ (cerebrospinal fluid) 仵ÃǨ à¾×è;ÔÊÙ¨¹ìÇèÒà«ÅÅìã¹ÃкºÀÙÁÔ¤ØéÁ¡Ñ¹¢Í§ÃèÒ§¡ÒÂÁըӹǹÁÒ¡¢Öé¹ËÃ×ÍäÁè «Öè§à»ç¹ÊÑ­­Ò³ºÍ¡ÇèÒÁѹ·Ó§Ò¹ÁÒ¡¢Öé¹à¡Ô´»¯ÔÃÔÂÒàÅè¹§Ò¹â¨ÁµÕ»ÃÐÊÒ·Êèǹ¡ÅÒ§

 

 

ÃÙ»¹ÕéáÊ´§»¯Ô¡ÔÃÔÂÒÀÙÁÔ¤ØéÁ¡Ñ¹·Õèà¡Ô´ºÃÔàdzá¼è¹¡Ñé¹ÃÐËÇèÒ§àÅ×Í´¡ÑºÊÁͧ·ÕèàÃÕ¡ÇèÒ Blood Braain Barier  áÅСÅä¡¡Ò÷ӧҹ¢Í§ÂÒ Daclizumab áÅÐ Natalizumab ·ÕèãªéÃÑ¡ÉÒâä¹Õé

·ÕèÁÒ http://www-ermm.cbcu.cam.ac.uk/05008926h.htm

 

»Ñ¨¨ØºÑ¹ÂѧäÁèÁÕÂÒÃÑ¡ÉÒâä¹ÕéãËéËÒ¢Ҵä´é ÁÕà¾Õ§ÂÒºÃÃà·ÒÍÒ¡ÒÃã¹ÃÐÂзÕèÁÕ¡ÒÃÍÑ¡àʺà·èÒ¹Ñé¹ àÃÕ¡ÇèÒ Disease modifying medicines ¹Í¡¨Ò¡¹ÕéÂѧÁÕ¡ÒÃá¾·Âì·Ò§àÅ×Í¡·ÕèªèÇ·ØàÅÒÍÒ¡ÒÃàªè¹ ¡Òýѧà¢çÁ (acupuncture), ä¤âÃá¾Ã¡µÔ¡ (chiropractic), ÂÒÊÁعä¾Ã (herbal medicine), á¹Ç¡ÒÃÃÑ¡ÉÒẺâÍÁÔâÍ¾Ò¸Õ (homeopathy) áÅÐá¹Ç¡ÒÃÃÑ¡ÉÒẺÍÍÊ·ÕâÍ¾Ò¸Õ (osteopathy) à»ç¹µé¹

                ÊÒõéҹ͹ØÁÙÅÍÔÊÃÐáÅÐÇÔµÒÁÔ¹à»ç¹·Ò§àÅ×͡˹Öè§·Õè¹èÒʹ㨠áµèÂѧäÁèÁÕËÅÑ¡°Ò¹á¹èªÑ´à¡ÕèÂǡѺ»ÃÐÊÔ·¸ÔÀҾ㹡ÒÃÃÑ¡ÉÒ ÇÔ·ÂÒ¡Ò÷Õèà»ç¹¤ÇÒÁËÇѧãËÁè㹡ÒÃÃÑ¡ÉÒâäàÍçÁàÍÊáµèÂѧÍÂÙèÃÐËÇèÒ§¡ÒÃÈÖ¡ÉÒÇԨѤ×Í ¡ÒÃãªéà«ÅÅìµé¹¡Óà¹Ô´¢Í§Ãкº»ÃÐÊÒ· (neural stem cell) ·ÕèÊÒÁÒöà¨ÃÔ­¾Ñ²¹Òä»à»ç¹ oligodendrocyte precursor cells «Öè§âÍÅÔâ¡à´¹â´Ã䫵ì¹ÕéÍÒ¨ªèÇÂÊÃéÒ§äÁÍÕÅÔ¹ä»ËØéÁáÍ¡«Í¹à¾×èÍ·´á·¹Êèǹ·Õè¶Ù¡·ÓÅÒÂã¹Ãкº»ÃÐÊÒ·Êèǹ¡ÅÒ§ä´é

 

   

ÃÙ»¹ÕéáÊ´§¡Åä¡¡ÒùÓÊè§à«ÅÅìµé¹¡Óà¹Ô´ neural precursor cell ¨Ò¡ÃкºäËÅàÇÕ¹âÅËÔµ ¼èÒ¹ Blood Brain Barier à¢éÒä»ÂѧÊÁͧ«Ö觨ҡ¹Ñ鹨Ðà»ÅÕè¹ä»à»ç¹à«ÅÅìâÍÅÔâ¡à´¹â´Ã䫵ìà¾×èÍÊÃéÒ§àÂ×èÍäÁÍÕÅÔ¹·´á·¹Êèǹ·Õè¶Ù¡·ÓÅÒÂä»

·ÕèÁÒ http://www.rsna.org/rsna/media/pr2004/pr_stemcells_may_hold_promise2.html

 

 

 

 

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Âé͹ä»àÁ×èÍÇѹ·Õè 3 ¾ÄȨԡÒ¹ ¤.È.1906 (¾.È. 2449) 㹡ÒûÃЪØÁÇÔªÒ¡Òâͧ Society of Southern German Psychiatrists ¤ÃÑé§·Õè 37 «Ö觨Ѵ·ÕèàÁ×ͧ·ÙºÔ§à§¹ »ÃÐà·ÈàÂÍÃÁ¹Õ ¹ÒÂá¾·ÂìÍÒâÅÍÔÊ ÍÑÅä«àÁÍÃì (Alois Alzheimer) ä´é¹ÓàʹÍÅѡɳзҧ»ÃÐÊÒ·¾ÂÒ¸ÔÇÔ·ÂÒáÅÐÍÒ¡Ò÷ҧ¤ÅÔ¹Ô¡¢Í§âä¹Õéà»ç¹¤ÃÑé§áá ËÅѧ¨Ò¡¹Ñé¹àÍÁÔÅ à¤Ãçºà¾ÅÕ¹  (Emil Kraepelin) ¡çä´éµÑ駪×èÍâä¹ÕéµÒÁ¼Ùé¤é¹¾º¤×Í âäÍÑÅä«àÁÍÃì (Alzheimer’s disease)

㹪èǧàÇÅҴѧ¡ÅèÒǹÑé¹ ¹ÒÂá¾·ÂìÍÑÅä«àÁÍÃìà»ç¹ËÑÇ˹éÒËéͧ»¯ÔºÑµÔ¡ÒáÒÂÇÔÀÒ¤ (Anatomical Laboratory) ·Õè Royal Psychiatric Clinic áËè§ÁËÒÇÔ·ÂÒÅÑÂÁÔǹԤ (University of Munich) »ÃÐà·ÈàÂÍÃÁ¹Õ à¢ÒÂéÒÂÁÒÍÂÙè·Õè¹ÕèàÁ×èÍ»Õ ¤.È. 1903 â´Â¡è͹˹éÒ¹Õéà¢Ò·Ó§Ò¹·ÕèʶҺѹÍÒ¡ÒûèÇ·ҧ¨ÔµáÅÐÅÁºéÒËÁ٢ͧà·ÈºÒÅ (Municipal Institution for the Mentally Ill and Epileptics) ã¹àÁ×ͧá¿Ã§¡ìà¿ÔÃì·«Öè§à»ç¹Ê¶Ò¹·Õè·Õèà¢Òä´éÃѺ¡ÒöèÒ·ʹ¤ÇÒÁÃÙé·Ò§´éÒ¹¾ÂÒ¸ÔÇÔ·ÂҢͧÊÁͧ (brain histopathology) ¨Ò¡¹Ò¿Ãѹ«ì ¹ÔÊà«ÔÅ (Franz Nissl) (¹Ò¹ÔÊà«ÔÅ ¤¹¹ÕéáËÅФÃѺ·Õèà»ç¹¤¹¤Ô´¤é¹ÇÔ¸Õ¡ÒÃÂéÍÁà«ÅÅìÊÁͧËÃ×Í Nissl Staining method ·ÓãËéàÃÒÊÒÁÒöÁͧàËç¹â¤Ã§ÊÃéÒ§¢Í§à«ÅÅì¢Í§à«ÅÅìÊÁͧáÅÐ¡ÅØèÁâ»ÃµÕ¹·ÕèµÔ´ÊÕÂéÍÁ·ÕèàÃÕ¡ÇèÒ Nissl Bodies)

ã¹à´×͹¾ÄȨԡÒ¹ ¤.È. 1901 ¹ÒÂá¾·ÂìÍÑÅä«àÁÍÃìä´éÃѺ¼Ùé»èÇÂË­Ô§·Õèª×èÍÍÍ¡ØÊà·Í à´. (Auguste D.) ÍÒÂØ 51 »Õ à¢éÒÃѺ¡ÒÃÃÑ¡ÉÒ·Õèâç¾ÂÒºÒŢͧàÁ×ͧá¿Ã§¡ìà¿ÔÃì·â´ÂÁÕÍÒ¡ÒÃËÅÑ¡¤×Í ¤ÇÒÁ¨ÓàÊ×èÍÁ¢Ñé¹Ãعáç (progressive memory loss), focal symptoms, àËç¹ÀÒ¾«é͹ (delusions), »ÃÐÊÒ·ËÅ͹ (hallucinations) ã¹»Õ 1906 ÍÍ¡ØÊà·Í à´.ä´éàÊÕªÕÇԵŧ ÊÁͧ¢Í§à¸Í¶Ù¡Êè§ä»ãËé¹ÒÂá¾·ÂìÍÑÅä«àÁÍÃìÇÔà¤ÃÒÐËì·ÕèÁÔǹԤ ã¹·ÕèÊØ´ÍÑÅä«àÁÍÃì¡çä´éãªéà·¤¹Ô¤¡ÒÃÂéÍÁà«ÅÅìẺ Silver staining method ¢Í§ Max Bielschowsky ·Õèä´é¹ÓàʹÍÇÔ¸Õ¹ÕéàÁ×èÍÊÕè»Õ¡è͹˹éÒ  ¼Å¡Ò÷´Åͧ¢Í§ÍÑÅä«àÁÍÃìä´éáÊ´§¶Ö§ neuritic plaques (µèÍÁÒ¾ºÇèÒ»ÃСͺ´éÇÂ¡ÅØèÁ¢Í§ amyloid beta peptides «Öè§ÍÂÙèÀÒ¹͡à«ÅÅì) áÅÐ  neurofibillay tangles (ÀÒÂËÅѧ¾ºÇèÒ»ÃСͺ´éÇÂ¡ÅØèÁ¢Í§ hyperphosphorylated Tua protein «Öè§ÍÂÙèÀÒÂã¹à«ÅÅì) «Öè§à»ç¹Åѡɳзҧ¾ÂÒ¸ÔÇÔ·ÂÒËÅÑ¡¢Í§âäâäÍÑÅä«àÁÍÃì·Õèãªéà»ç¹ËÅÑ¡°Ò¹ÍéÒ§ÍÔ§¨Çº¨¹»Ñ¨¨ØºÑ¹ «Ö觻Ѩ¨ØºÑ¹¹ÕéÁÕ¼Ùé»èÇÂâäÍÑÅä«àÁÍÃì·ÑèÇâÅ¡»ÃÐÁÒ³ 20 ÅéÒ¹¤¹áÅéǤÃѺ

àÍ¡ÊÒÃÍéÒ§ÍÔ§ Michel Goedert and Maria Grazia Spillatini, A Century of Alzheimer’s disease, Science Vol 314, 777-780.